Attinder Chadha, Yu Yanai, Hiromu Oide, Yuichi Wakana, Hiroki Inoue, Saradindu Saha, Mitsuo Tagaya, Kohei Arasaki, Shaeri Mukherjee. Legionella uses host Rab GTPases and BAP31 to create a unique ER niche. bioRxiv 2024. doi: https://doi.org/10.1101/2024.05.10.593622
Steinbach A, Bhadkamkar V, Jimenez-Morales D, Stevenson E, Jang GM, Krogan NJ, Swaney DL, Mukherjee S. Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila Mol Biol Cell 2024 PMID: 38117589 DOI: 10.1091/mbc.E23-06-0260
Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S. A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response. Nat Cell Biol 2023 PMID: 37857833 DOI: 10.1038/s41556-023-01248-z
Highlighted in News and Views Nat Cell Biol 2023 Hijacking host ribosomes via tRNA mimicry
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald JG, Shen K, Ma DK. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Nat. Commun 2022. PMID: 36357390 DOI: 10.1038/s41467-022-34450-y
Ibe NU, Subramanian A, Mukherjee S. Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors Life Sci Alliance. 2021.Oct 11;4(12):e202101247. doi: 10.26508/lsa.202101247. Print 2021 Dec. PMID: 34635501
Julia Noack, David Jimenez-Morales, Erica Stevenson, Tom Moss, Gwendolyn Jang, Nevan J. Krogan, Danielle L. Swaney, Shaeri Mukherjee. Dynamic proteomics profiling of Legionella pneumophila infection unveils modulation of the host mitochondrial stress response pathway. bioRxiv 2020.05.19.105395; doi: https://doi.org/10.1101/2020.05.19.105395
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.. Nature 2020 Nature Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9. Epub 2020 Apr 30. PMID: 32353859
Noack J, Mukherjee S. "Make way": Pathogen exploitation of membrane traffic. Curr Opin Cell Biol. 2020 Aug;65:78-85. doi: 10.1016/j.ceb.2020.02.011. Epub 2020 Mar 29. PMID: 32234681 Review.
Camus SM, Camus MD, Figueras-Novoa C, Boncompain G, Sadacca LA, Esk C, Bigot A, Gould GW, Kioumourtzoglou D, Perez F, Bryant NJ, Mukherjee S*, Brodsky FM*. CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis. J Cell Biol. 2020 Jan 6;219(1):e201812135. doi: 10.1083/jcb.201812135. PMID: 31863584 * Co-corresponding author
Jeng EE, Bhadkamkar V, Ibe NU, Gause H, Jiang L, Chan J, Jian R, Jimenez-Morales D, Stevenson E, Krogan NJ, Swaney DL, Snyder MP, Mukherjee S*, Bassik MC.*. Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.. Cell Host Microbe. 2019 Oct 9;26(4):551-563.e6. doi: 10.1016/j.chom.2019.08.017. Epub 2019 Sep 17. PMID: 31540829 * Co-corresponding author
Moss MS, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM*, and Mukherjee S*. A Legionella pneumophila kinase phosphorylates the Hsp70 chaperone family to inhibit eukaryotic protein synthesis. Cell Host Microbe. 2019 Mar 13;25(3):454-462.e6. doi: 10.1016/j.chom.2019.01.006. Epub 2019 Feb 28. PMID: 30827827 * Co-corresponding author
Cornejo E, Schlaermann P, Mukherjee, S. How to rewire the host cell: A home improvement guide for intracellular bacteria. J Cell Biol. 2017 Dec 4;216(12):3931-3948. doi: 10.1083/jcb.201701095. Epub 2017 Nov 2. PMID: 29097627
Levin RS, Hertz NT, Burlingame AL, Shokat KM*, Mukherjee, S*. Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen. Proc Natl Acad Sci USA. 2016 Aug 16;113(33):E4776-83. doi: 10.1073/pnas.1608355113. Epub 2016 Aug 1. PMID: 27482120 * Co-corresponding author
Treacy-Abarca S & Mukherjee S. Legionella suppresses the host unfolded protein response via multiple mechanisms. Nat. Commun. 2015 Jul 29;6:7887. doi: 10.1038/ncomms8887. PMID: 26219498
Horenkamp FA*, Mukherjee S*, Alix E*, Schauder CM, Hubber AM, Roy CR, Reinisch KM. Legionella pneumophila subversion of host vesicular transport by SidC effector proteins. Traffic. 2014 May;15(5):488-99. doi: 10.1111/tra.12158. Epub 2014 Mar 12. PMID: 24483784 * Equal Contribution
Campanacci V, Mukherjee S, Roy CR, Cherfils J. Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain. EMBO J. 2013 May 15;32(10):1469-77. doi: 10.1038/emboj.2013.82. Epub 2013 Apr 9. PMID: 23572077
Alix E*, Mukherjee S*, Roy CR. Subversion of membrane transport pathways by vacuolar pathogens. J Cell Biol. 2011 Dec 12;195(6):943-52. doi: 10.1083/jcb.201105019. Epub 2011 Nov 28. PMID: 22123831 * Equal Contribution
Mukherjee S*, Liu X*, Arasaki K, McDonough J, Galán JE, Roy CR. Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature. 2011 2011 Aug 7;477(7362):103-6. doi: 10.1038/nature10335. PMID: 21822290. * Equal Contribution
Radulescu AE*, Mukherjee S*, Shields D. The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression. J Biol Chem. 2011 2011 Jun 17;286(24):21915-26. doi: 10.1074/jbc.M110.209460. Epub 2011 May 2. PMID: 21536679. * Equal Contribution
Biswas A, Mukherjee S, Das S, Shields D, Chow CW, Maitra U. Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6. J Biol Chem. 2011 Jan 28;286(4):3129-38. doi: 10.1074/jbc.M110.188565. Epub 2010 Nov 17. PMID: 21084295
Roy CR, Mukherjee S. Bacterial FIC Proteins AMP Up Infection. Sci Signal. 2009 Mar 17;2(62):pe14. doi: 10.1126/scisignal.262pe14. PMID: 19293428 Review.
Mukherjee S, Shields D. Nuclear import is required for the pro-apoptotic function of the Golgi protein p115. J Biol Chem. 2009 Jan 16;284(3):1709-17. doi: 10.1074/jbc.M807263200. Epub 2008 Nov 21. PMID: 19028683
Mukherjee S, Chiu R, Leung SM, Shields D. Fragmentation of the Golgi apparatus: an early apoptotic event independent of the cytoskeleton. Traffic. 2007 Apr;8(4):369-78. doi: 10.1111/j.1600-0854.2007.00542.x. PMID: 17394485
Sengupta R, Sahoo R, Mukherjee S, Regulski M, Tully T, Stuehr DJ, Ghosh S. Characterization of Drosophila nitric oxide synthase: a biochemical study. Biochem Biophys Res Commun. 2003 Jun 27;306(2):590-7. doi: 10.1016/s0006-291x(03)01003-9. PMID: 12804606
Chiu R, Novikov L, Mukherjee S, Shields D. A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis. J Cell Biol. 2002 Nov 25;159(4):637-48. doi: 10.1083/jcb.200208013. Epub 2002 Nov 18. PMID: 12438416